JC viruria and kidney disease in APOL1 risk genotype individuals: is this a clue to a gene × environment interaction?
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چکیده
منابع مشابه
JC polyoma virus interacts with APOL1 in African Americans with non-diabetic nephropathy
Individuals with HIV infection and two apolipoprotein L1 gene (APOL1) risk variants frequently develop nephropathy. Here we tested whether non-HIV viral infections influence nephropathy risk via interactions with APOL1 by assessing APOL1 genotypes and presence of urine JC and BK polyoma virus and plasma HHV6 and CMV by quantitative polymerase chain reaction. We analyzed 300 samples from unrelat...
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Gene sequence mutations may alter mRNA transcription, transcript stability, protein translation, protein stability and protein folding. Apolipoprotein L1 (APOL1) has two sets of sequence variants that are risk factors for kidney disease development, APOL1G1 (substitution mutation) and APOL1G2 (deletion mutation). Our present study focuses on the impact of these variants on APOL1 mRNA transcript...
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15 صفحه اولA gene-environment interaction between inferred kallikrein genotype and potassium.
Urinary kallikrein excretion has been shown statistically to be partially determined by a major gene in large Utah pedigrees with the use of segregation analysis. A previous twin analysis of environmental factors influencing urinary kallikrein level showed that urinary potassium twin differences were strongly related to differences in urinary kallikrein. The present study uses 769 individuals i...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2013
ISSN: 0085-2538
DOI: 10.1038/ki.2013.299